Capillary stop valve actuation by thermo-pneumatic- pressure for lab-on-chip systems

Lab-on-chip systems for integrated bioanalyses

Biomolecular detection systems based on microfluidics are often called lab-on-chip systems. To fully benefit from the miniaturization resulting from microfluidics, one aims to develop 'from sample-to-answer' analytical systems, in which the input is a raw or minimally processed biological, food/feed or environmental sample and the output is a quantitative or qualitative assessment of one or mor...

Self-actuated, thermo-responsive hydrogel valves for lab on a chip.

An easy to fabricate, thermally-actuated, self-regulated hydrogel valve for flow control in pneumatically driven, microfluidic systems is described. This microvalve takes advantage of the properties of the hydrogel, poly(N-isopropylacrylamide), as well as the aqueous fluid itself to realize flow control. The valve was designed for use in a diagnostic system fabricated with polycarbonate and aim...

Polymer multilevel lab-on-chip systems for electrochemical sensing

CMOS Circuits and Systems for Lab‐on‐a‐Chip Applications

Complementary metal oxide semiconductor (CMOS) technology allows the functional integration of sensors, signal conditioning, processing circuits and development of fully electronic integrated lab‐on‐a‐chip. On the other hand, lab‐on‐a‐chip is a technology which changed the traditional way by which biological samples are inspected and tested in laboratories. A lab‐on‐a‐chip consists of four main...

Moving-part-free microfluidic systems for lab-on-a-chip

Microfluidic systems are part of an emerging technology which deals with minute amounts of liquids (biological samples and reagents) on a small scale. They are fast, compact and can be made into a highly integrated system to deliver sample purification, separation, reaction, immobilization, labelling, as well as detection, thus are promising for applications such as lab-on-a-chip and handheld h...